The ÖzU Çekmeköy Campus has been designed by RMJM, a firm that has also designed campuses and buildings for many of the world's leading universities. Among other projects designed for universities by the RMJM architecture group are the Columbia University Medical Center, the William Gates Building at Cambridge University, the Bowen Building at Princeton University, the Chemistry Research Building at Oxford University, and the University of West Scotland Ayr Campus. The defining features of the buildings at Özyeğin University's Çekmeköy Campus, where the use of natural materials is emphasized, are light and transparency. The campus, built with a flexible and modular approach, serves as an example of sustainability with its economical use of resources and operational costs.

Since its establishment, ÖzU has aimed to be an environmentally friendly university and sustainability is one of the main items in the university's initial founding strategy. In this context, three buildings constructed on the campus have received the LEED Gold Certification according to the measurements of the American Green Building Council. The third building constructed on campus, AB3: ScOLa, is one of the most energy-efficient academic buildings in Turkey. The ScOLa, which was built as part of a European Union 7th Framework Programme project, NEED4B 'New Energy Efficiency in Buildings', by ÖzU Energy, Environment, and Economy Center (EÇEM), consumes only about 20% of the energy of an average academic building in Turkey. The NEED4B Project, with a budget of 1.3 million Euros, is the highest-funded energy project received by a university in Turkey. Another project won by EÇEM is the TRIBE Project, which is the first project supported by the European Union Horizon 2020 program in Turkey. Started in 2015, TRIBE was selected first among 94 projects, aiming to make the ÖzU AB1 building more energy-efficient based on user options and the concept of the internet of things.

In addition to LEED certificates, ÖzU is the first university in Turkey to receive both the ISO 14001 Environmental Management System certificate and the OHSAS 18001 Occupational Health and Safety certificate. ISO 14001 is an environmental management system that aims to manage and improve an organization's environmental protection performance. OHSAS 18001 is a certificate that includes occupational health and environmental safety and provides a framework for identifying, controlling, and reducing risks in the workplace.

Furthermore, the university has installed solar panels with a capacity of 376 kWp in collaboration with Fina Energy and has seven green roofs. Since the establishment of the university, the Energy Distribution Center, which monitors all energy production and consumption on campus, detailed building automation applications, and organized water and waste management studies have been in operation.